So what is the best way to remove floor tile mastic. Depends on the substrate and the intended new floor covering. On concrete floors, bead blasting with perimeter clean up utilizing floor grinders will leave a surface suitable for epoxy application or new mastic and flooring material. Wood surface is not suitable for bead blasting and chemical stripper will suffice. If the building is going to be demolished, cutting an old plywood floor out and disposing of it as asbestos contaminated may be more cost effective than mastic abatement.